Unexpected tolerance of alpha-cleavage of the prion protein to sequence variations.
The cellular form of the prion protein, PrP(C), undergoes extensive proteolysis at the alpha site (109K [see text]H110). Expression of non-cleavable PrP(C) mutants in transgenic mice correlates with neurotoxicity, suggesting that alpha-cleavage is important for PrP(C) physiology. To gain insights in...
Bewaard in:
| Hoofdauteurs: | , , , , , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science (PLoS)
2010-02-01
|
| Reeks: | PLoS ONE |
| Online toegang: | http://europepmc.org/articles/PMC2817006?pdf=render |
| Tags: |
Geen labels, Wees de eerste die dit record labelt!
|