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Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells

Abstract The targeted elevation of the labile iron pool (LIP) represents the most direct and effective strategy to induce ferroptosis in cancer cells. However, the efficiency of increasing LIP to induce ferroptosis via iron supplementation is controversial due to the iron homeostasis between LIP and...

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Autori principali: Xin Wang, Tianyi Zhang, Shuai Wang, Hanping Shi, Hong Dong, Yanning Huang, Wenjia Lai, Yiqiao Hu, Chunyan Yue
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-02-01
Serie:Journal of Nanobiotechnology
Soggetti:
Non-canonical ferroptosis
Iron homeostasis
HMOX1
Bio-nanocomplex
CBS
Labile iron pool
Accesso online:https://doi.org/10.1186/s12951-025-03117-3
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