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Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells

Abstract The targeted elevation of the labile iron pool (LIP) represents the most direct and effective strategy to induce ferroptosis in cancer cells. However, the efficiency of increasing LIP to induce ferroptosis via iron supplementation is controversial due to the iron homeostasis between LIP and...

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Principais autores: Xin Wang, Tianyi Zhang, Shuai Wang, Hanping Shi, Hong Dong, Yanning Huang, Wenjia Lai, Yiqiao Hu, Chunyan Yue
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-02-01
coleção:Journal of Nanobiotechnology
Assuntos:
Non-canonical ferroptosis
Iron homeostasis
HMOX1
Bio-nanocomplex
CBS
Labile iron pool
Acesso em linha:https://doi.org/10.1186/s12951-025-03117-3
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