B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

Cobalt‐corrins, such as coenzyme B12 (AdoCbl) and methylcobalamin (MeCbl), are indispensable enzyme‐cofactors found across all kingdoms of life. Their Rh‐homologues are promising coordination‐chemical and structural B12‐mimics. Herein, the preparation of methylrhodibalamin (MeRhbl) in over 90% yield...

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Bibliographische Detailangaben
Hauptverfasser: Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley-VCH 2025-11-01
Schriftenreihe:ChemistryEurope
Schlagworte:
crystal structures
enzyme inhibitors
growth inhibitors
organometallic catalysts
vitamin B12
Online Zugang:https://doi.org/10.1002/ceur.202500157
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