B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

Cobalt‐corrins, such as coenzyme B12 (AdoCbl) and methylcobalamin (MeCbl), are indispensable enzyme‐cofactors found across all kingdoms of life. Their Rh‐homologues are promising coordination‐chemical and structural B12‐mimics. Herein, the preparation of methylrhodibalamin (MeRhbl) in over 90% yield...

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Huvudupphov:	Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Wiley-VCH 2025-11-01
Serie:	ChemistryEurope
Ämnen:	crystal structures enzyme inhibitors growth inhibitors organometallic catalysts vitamin B12
Länkar:	https://doi.org/10.1002/ceur.202500157
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