B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

Cobalt‐corrins, such as coenzyme B12 (AdoCbl) and methylcobalamin (MeCbl), are indispensable enzyme‐cofactors found across all kingdoms of life. Their Rh‐homologues are promising coordination‐chemical and structural B12‐mimics. Herein, the preparation of methylrhodibalamin (MeRhbl) in over 90% yield...

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Principais autores:	Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley-VCH 2025-11-01
Series:	ChemistryEurope
Assuntos:	crystal structures enzyme inhibitors growth inhibitors organometallic catalysts vitamin B12
Acceso en liña:	https://doi.org/10.1002/ceur.202500157
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