B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

Cobalt‐corrins, such as coenzyme B12 (AdoCbl) and methylcobalamin (MeCbl), are indispensable enzyme‐cofactors found across all kingdoms of life. Their Rh‐homologues are promising coordination‐chemical and structural B12‐mimics. Herein, the preparation of methylrhodibalamin (MeRhbl) in over 90% yield...

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Auteurs principaux: Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler
Format: Artigo
Langue:Inglês
Publié: Wiley-VCH 2025-11-01
Collection:ChemistryEurope
Sujets:
crystal structures
enzyme inhibitors
growth inhibitors
organometallic catalysts
vitamin B12
Accès en ligne:https://doi.org/10.1002/ceur.202500157
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