B12‐Cofactor Inactivation by Cobalt to Rhodium Mutation in Methylrhodibalamin: An Antivitamin B12 and Antibiotic

Cobalt‐corrins, such as coenzyme B12 (AdoCbl) and methylcobalamin (MeCbl), are indispensable enzyme‐cofactors found across all kingdoms of life. Their Rh‐homologues are promising coordination‐chemical and structural B12‐mimics. Herein, the preparation of methylrhodibalamin (MeRhbl) in over 90% yield...

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Autori principali:	Florian J. Widner, Klaus Wurst, Markus Ruetz, Christoph Kieninger, Christoph Kreutz, Michael D. Paxhia, Evelyne Deery, Martin J. Warren, Bernhard Kräutler
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley-VCH 2025-11-01
Serie:	ChemistryEurope
Soggetti:	crystal structures enzyme inhibitors growth inhibitors organometallic catalysts vitamin B12
Accesso online:	https://doi.org/10.1002/ceur.202500157
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