Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity

ABSTRACT Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of exogenous guanosine and underscoring t...

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Detalhes bibliográficos

Principais autores:	Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2025-04-01
Colecção:	mBio
Assuntos:	pyruvate kinase nucleotide metabolism glycolysis GTP (p)ppGpp
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.03798-24
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