Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity

ABSTRACT Guanosine triphosphate (GTP) is essential for macromolecular biosynthesis, and its intracellular levels are tightly regulated in bacteria. Loss of the alarmone (p)ppGpp disrupts GTP regulation in Bacillus subtilis, causing cell death in the presence of exogenous guanosine and underscoring t...

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Autors principals:	Fukang She, Kuanqing Liu, Brent W. Anderson, Tippapha Pisithkul, Yanxiu Li, Danny K. Fung, Tyler McCue, William Mulhern, Daniel Amador-Noguez, Jue D. Wang
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-04-01
Col·lecció:	mBio
Matèries:	pyruvate kinase nucleotide metabolism glycolysis GTP (p)ppGpp
Accés en línia:	https://journals.asm.org/doi/10.1128/mbio.03798-24
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