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Development and optimization of multivesicular gefitinib liposomal transdermal system employing lipoid S100 for breast cancer: pharmacokinetics, bioavailability, and skin irritation studies in Wistar rats

Abstract Background Conventional therapies in cancer treatment face challenges including drug resistance, lack of specificity, and severe adverse reactions. This study explores the potential of liposomal transdermal delivery systems as an alternative to current therapies with improved BA and PK. The...

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Principais autores: Jyoti S. Patel, Nulgumnalli Manjunathaiah Raghavendra, B. Sajeev Kumar
פורמט: Artigo
שפה:Inglês
יצא לאור: SpringerOpen 2024-11-01
סדרה:Future Journal of Pharmaceutical Sciences
נושאים:
Central composite design
Lipoid S100
Transdermal
Gefitinib
Liposomes
Multivesicular vesicle
גישה מקוונת:https://doi.org/10.1186/s43094-024-00729-8
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