Molecular docking, molecular dynamics simulation, preparation, and characterization of naltrexone-phospholipid complex: A novel cargo with improved loading into multivesicular liposomes

Naltrexone hydrochloride (NTX), a water-soluble opioid receptor antagonist, is prescribed widely for opioid and alcohol dependence and pain reduction. However, the significant limitations of NTX are low lipophilicity and extensive first-pass metabolism. This study aimed to design and prepare a novel...

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Principais autores:	Reihaneh Yousefi, Yasaman Rezaee, Fereshteh Bayat, Elham Rezaee, Leila Karami, Simin Dadashzadeh, Azadeh Haeri
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-07-01
coleção:	Results in Chemistry
Assuntos:	Naltrexone HCl Phospholipid complex Multivesicular liposomes Molecular docking Molecular dynamics simulation
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211715624003527
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