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Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation

<p>Abstract</p> <p>Background</p> <p>Eosinophils are critically involved in the pathogenesis of asthma. Nitric oxide (NO) is produced in high amounts in asthmatic lungs and has an important role as a regulator of lung inflammation. NO was previously shown to induce eosinophil apoptosis mediated via...

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Principais autores: Ilmarinen-Salo Pinja, Moilanen Eeva, Kinnula Vuokko L, Kankaanranta Hannu
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2012-08-01
Series:Respiratory Research
Assuntos:
Eosinophils
Apoptosis
Nitric oxide
Mitochondrial permeability transition
JNK
Reactive oxygen species
Acceso en liña:http://respiratory-research.com/content/13/1/73
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