The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice

Background: During Alzheimer’s disease (AD) progression, there is a decline in the bioactive sphingolipid sphingosine-1-phosphate (S1P). Previous research showed that FTY720, an S1P mimetic, prevented cognitive decline and reduced ceramide levels in transgenic mice with familial AD carrying the huma...

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Главные авторы:	Qian Luo, Simone M. Crivelli, Shenghua Zong, Caterina Giovagnoni, Daan van Kruining, Marina Mané-Damas, Sandra den Hoedt, Dusan Berkes, Helga E. De Vries, Monique T. Mulder, Jochen Walter, Etienne Waelkens, Rita Derua, Johannes V. Swinnen, Jonas Dehairs, Mario Losen, Pilar Martinez-Martinez
Формат:	Artigo
Язык:	Inglês
Опубликовано:	SAGE Publishing 2024-09-01
Серии:	Journal of Alzheimer's Disease Reports
Online-ссылка:	https://doi.org/10.3233/ADR-230053
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