Selective Knockdown of Ceramide Synthases Reveals Opposite Roles of Different Ceramide Species in Cardiac Homeostasis

<b>Background/Objectives:</b> Sphingolipids are a class of lipids that play important structural and functional roles in the cell. Specific ceramide species are distinguishable through the fatty acid that is acylated to the sphingosine backbone, leading to distinct biological activities. Generally,...

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Hauptverfasser:	Alexandra M. Wiley, Melissa A. Krueger, Jessica O. Becker, Matthew Karasu, Nona Sotoodehnia, Jason G. Umans, Andrew N. Hoofnagle, Sina A. Gharib, Rheem A. Totah, Rozenn N. Lemaitre
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2025-08-01
Schriftenreihe:	Metabolites
Schlagworte:	cell signaling ceramides lipids sphingolipids LC-MS cardiovascular disease
Online-Zugang:	https://www.mdpi.com/2218-1989/15/9/584
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