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Cellular zinc status alters chromatin accessibility and binding of p53 to DNA

ATAC-seq and transcription factor enrichment analysis reveal that perturbations in labile Zn 2+ alter chromatin accessibility and enrichment of transcription factor motifs in regions of open chromatin. Zn 2+ is an essential metal required by approximately 850 human transcription factors. How these p...

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Auteurs principaux: Daniel Ocampo, Leah J Damon, Lynn Sanford, Samuel E Holtzen, Taylor Jones, Mary A Allen, Robin D Dowell, Amy E Palmer
Format: Artigo
Langue:Inglês
Publié: Life Science Alliance LLC 2024-09-01
Collection:Life Science Alliance
Accès en ligne:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202402638
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