Wild-type p53 binds to the TATA-binding protein and represses transcription.

p53 activates transcription of genes with a p53 response element, and it can repress genes lacking the element. Here we demonstrate that wild-type but not mutant p53 inhibits transcription in a HeLa nuclear extract from minimal promoters. Wild-type but not mutant p53 binds to human TATA-binding prot...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Seto, E, Usheva, A, Zambetti, G P, Momand, J, Horikoshi, N, Weinmann, R, Levine, A J, Shenk, T
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1992
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50691/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1465435/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.24.12028
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