Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.
The insulin-like growth factor I receptor (IGF-I-R) plays a critical role in transformation events. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Tumor suppressor p53 is a nuclear transcription factor that blocks cell c...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38668/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710868/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8318 |
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