Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis

Objective: Pro-peptide precursors are processed into biologically active peptide hormones or neurotransmitters, each playing an essential role in physiology and disease. Genetic loss of function of a pro-peptide precursor results in the simultaneous ablation of all biologically-active peptides withi...

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Hlavní autoři:	Bhavani S. Sahu, Maria Razzoli, Seth McGonigle, Jean Pierre Pallais, Megin E. Nguyen, Masato Sadahiro, Cheng Jiang, Wei-Jye Lin, Kevin A. Kelley, Pedro Rodriguez, Rachel Mansk, Cheryl Cero, Giada Caviola, Paola Palanza, Loredana Rao, Megan Beetch, Emilyn Alejandro, Yuk Y. Sham, Andrea Frontini, Stephen R. Salton, Alessandro Bartolomucci
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2023-10-01
Edice:	Molecular Metabolism
Témata:	Pro-peptides Mass spectrometry Obesity Point mutation VGF Granins
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2212877823001151
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