Blocking microglial reactivity via purinergic receptors prevents subacute cognitive deficits after TIA

Abstract Our research presents a new animal model of transient ischemic attack (TIA) that mimics brief episodes without cell loss, but results in neuronal and behavioral deficits. We identified excessive microglial reactivity, driven by acute ATP release, as a key factor in post-TIA neurological def...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Gemma Llovera, Steffanie Heindl, Daniel P Varga, Nikolett Lenart, Sebastian Kallabis, Vanessa Göb, David Stegner, Raphael Escaig, Leo Nicolai, Nicolai Franzmeier, Felix Meissner, Adam Denes, Arthur Liesz
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2026-03-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	ATP Microglia TIA Purinergic Receptor Synapse
Online-Zugang:	https://doi.org/10.1038/s44321-026-00397-6
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