Ecto-5ʹ-nucleotidase/CD73 reduces COX-2 expression in activated macrophages
Abstract Extracellular ATP (eATP) is a significant contributor of inflammation through enhanced expression of cyclooxygenase 2 (COX-2). In this study, we explored whether overexpression of ectonucleotidases such as ecto-5’-nucleotidase (NT5E, or CD73), responsible for the hydrolysis of AMP to adenos...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2026-01-01
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| Serie: | Scientific Reports |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1038/s41598-025-34809-3 |
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