Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies

Por Evers, Melvin M., Toonen, Lodewijk J. A., van Roon-Mom, Willeke M. C.
Publicado em 2013

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice

Por Toonen, Lodewijk J.A., Rigo, Frank, van Attikum, Haico, van Roon-Mom, Willeke M.C.
Publicado no Mol Ther Nucleic Acids (2017)

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3

Por Toonen, Lodewijk J. A., Schmidt, Iris, Luijsterburg, Martijn S., van Attikum, Haico, van Roon-Mom, Willeke M. C.
Publicado no Sci Rep (2016)

Genetics, Mechanisms, and Therapeutic Progress in Polyglutamine Spinocerebellar Ataxias

Por Buijsen, Ronald A.M., Toonen, Lodewijk J.A., Gardiner, Sarah L., van Roon-Mom, Willeke M.C.
Publicado no Neurotherapeutics (2019)

Antisense-Mediated RNA Targeting: Versatile and Expedient Genetic Manipulation in the Brain

Por Zalachoras, Ioannis, Evers, Melvin M., van Roon-Mom, Willeke M. C., Aartsma-Rus, Annemieke M., Meijer, Onno C.
Publicado em 2011

Exploring the Transcriptome of Ciliated Cells Using In Silico Dissection of Human Tissues

Por Ivliev, Alexander E., 't Hoen, Peter A. C., van Roon-Mom, Willeke M. C., Peters, Dorien J. M., Sergeeva, Marina G.
Publicado em 2012

Osteopontin and phospho‐SMAD2/3 are associated with calcification of vessels in D‐CAA, an hereditary cerebral amyloid angiopathy

Por Grand Moursel, Laure, van der Graaf, Linda M., Bulk, Marjolein, van Roon‐Mom, Willeke M.C., van der Weerd, Louise
Publicado no Brain Pathol (2019)

Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Por Toonen, Lodewijk J.A., Casaca-Carreira, João, Pellisé-Tintoré, Maria, Mei, Hailiang, Temel, Yasin, Jahanshahi, Ali, van Roon-Mom, Willeke M.C.
Publicado no Nucleic Acid Ther (2018)

Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

Por Curtis, Maurice A., Penney, Ellen B., Pearson, Andree G., van Roon-Mom, Willeke M. C., Butterworth, Niqi J., Dragunow, Michael, Connor, Bronwen, Faull, Richard L. M.
Publicado em 2003

The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

Por van Hagen, Martijn, Piebes, Diewertje G. E., de Leeuw, Wim C., Vuist, Ilona M., van Roon-Mom, Willeke M. C., Moerland, Perry D., Verschure, Pernette J.
Publicado no BMC Genomics (2017)

Co-expression Patterns between ATN1 and ATXN2 Coincide with Brain Regions Affected in Huntington’s Disease

Por Keo, Arlin, Aziz, N. Ahmad, Dzyubachyk, Oleh, van der Grond, Jeroen, van Roon-Mom, Willeke M. C., Lelieveldt, Boudewijn P. F., Reinders, Marcel J. T., Mahfouz, Ahmed
Publicado no Front Mol Neurosci (2017)

Bioenergetics in fibroblasts of patients with Huntington disease are associated with age at onset

Por Gardiner, Sarah L., Milanese, Chiara, Boogaard, Merel W., Buijsen, Ronald A.M., Hogenboom, Marye, Roos, Raymund A.C., Mastroberardino, Pier G., van Roon-Mom, Willeke M.C., Aziz, N. Ahmad
Publicado no Neurol Genet (2018)

Targeting Several CAG Expansion Diseases by a Single Antisense Oligonucleotide

Por Evers, Melvin M., Pepers, Barry A., van Deutekom, Judith C. T., Mulders, Susan A. M., den Dunnen, Johan T., Aartsma-Rus, Annemieke, van Ommen, Gert-Jan B., van Roon-Mom, Willeke M. C.
Publicado em 2011

Selection and characterization of llama single domain antibodies against N-terminal huntingtin

Por Schut, Menno H., Pepers, Barry A., Klooster, Rinse, van der Maarel, Silvère M., el Khatabi, Mohamed, Verrips, Theo, den Dunnen, Johan T., van Ommen, Gert-Jan B., van Roon-Mom, Willeke M. C.
Publicado no Neurol Sci (2014)

Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson's disease

Por Milanese, Chiara, Payán‐Gómez, César, Galvani, Marta, Molano González, Nicolás, Tresini, Maria, Nait Abdellah, Soraya, van Roon‐Mom, Willeke M. C., Figini, Silvia, Marinus, Johan, van Hilten, Jacobus J., Mastroberardino, Pier G.
Publicado no Mov Disord (2019)

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates

Por Schut, Menno H., Patassini, Stefano, Kim, Eric H., Bullock, Jocelyn, Waldvogel, Henry J., Faull, Richard L. M., Pepers, Barry A., den Dunnen, Johan T., van Ommen, Gert-Jan B., van Roon-Mom, Willeke M. C.
Publicado no PLoS One (2017)

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease

Por Hensman Moss, Davina J., Flower, Michael D., Lo, Kitty K., Miller, James R. C., van Ommen, Gert-Jan B., ’t Hoen, Peter A. C., Stone, Timothy C., Guinee, Amelia, Langbehn, Douglas R., Jones, Lesley, Plagnol, Vincent, van Roon-Mom, Willeke M. C., Holmans, Peter, Tabrizi, Sarah J.
Publicado no Sci Rep (2017)

Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

Por Toonen, Lodewijk J. A., Overzier, Maurice, Evers, Melvin M., Leon, Leticia G., van der Zeeuw, Sander A. J., Mei, Hailiang, Kielbasa, Szymon M., Goeman, Jelle J., Hettne, Kristina M., Magnusson, Olafur Th., Poirel, Marion, Seyer, Alexandre, ‘t Hoen, Peter A. C., van Roon-Mom, Willeke M. C.
Publicado no Mol Neurodegener (2018)

Brain Transcriptomic Analysis of Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type

Por Grand Moursel, Laure, van Roon-Mom, Willeke M. C., Kiełbasa, Szymon M., Mei, Hailiang, Buermans, Henk P. J., van der Graaf, Linda M., Hettne, Kristina M., de Meijer, Emile J., van Duinen, Sjoerd G., Laros, Jeroen F. J., van Buchem, Mark A., ‘t Hoen, Peter A. C., van der Maarel, Silvère M., van der Weerd, Louise
Publicado no Front Aging Neurosci (2018)

Huntingtin gene repeat size variations affect risk of lifetime depression

Por Gardiner, Sarah L., van Belzen, Martine J., Boogaard, Merel W., van Roon-Mom, Willeke M. C., Rozing, Maarten P., van Hemert, Albert M., Smit, Johannes H., Beekman, Aartjan T. F., van Grootheest, Gerard, Schoevers, Robert A., Oude Voshaar, Richard C., Roos, Raymund A. C., Comijs, Hannie C., Penninx, Brenda W. J. H., van der Mast, Roos C., Aziz, N. Ahmad
Publicado no Transl Psychiatry (2017)