Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates

Huntington disease is associated with elongation of a CAG repeat in the HTT gene that results in a mutant huntingtin protein. Several studies have implicated N-terminal huntingtin protein fragments in Huntington disease pathogenesis. Ideally, these fragments are studied in human brain tissue. Howeve...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schut, Menno H., Patassini, Stefano, Kim, Eric H., Bullock, Jocelyn, Waldvogel, Henry J., Faull, Richard L. M., Pepers, Barry A., den Dunnen, Johan T., van Ommen, Gert-Jan B., van Roon-Mom, Willeke M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453542/
https://ncbi.nlm.nih.gov/pubmed/28570578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178556
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