Intracerebroventricular Administration of a 2′-O-Methyl Phosphorothioate Antisense Oligonucleotide Results in Activation of the Innate Immune System in Mouse Brain

Antisense oligonucleotides (AONs) are versatile molecules that can be used to modulate gene expression by binding to RNA. The therapeutic potential of AONs appears particularly high in the central nervous system, due to excellent distribution and uptake in brain cells, as well as good tolerability i...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Toonen, Lodewijk J.A., Casaca-Carreira, João, Pellisé-Tintoré, Maria, Mei, Hailiang, Temel, Yasin, Jahanshahi, Ali, van Roon-Mom, Willeke M.C.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899290/
https://ncbi.nlm.nih.gov/pubmed/29565739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0705
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