Immunomodulatory and Kidney-Protective Effects of the Human Chorionic Gonadotropin Derivate EA-230

由 van Groenendael, Roger, Kox, Matthijs, van Eijk, Lucas T., Pickkers, Peter
發表在 Nephron Clin Pract (2018)

Pharmacokinetics, safety and tolerability of the novel β‐hCG derived immunomodulatory compound, EA‐230

由 van Groenendael, Roger, Aarnoutse, Rob, Kox, Matthijs, van Eijk, Lucas, Pickkers, Peter
發表在 Br J Clin Pharmacol (2019)

A randomized double‐blind, placebo‐controlled clinical phase IIa trial on safety, immunomodulatory effects and pharmacokinetics of EA‐230 during experimental human endotoxaemia...

由 van Groenendael, Roger, Kox, Matthijs, Leijte, Guus, Koeneman, Bouke, Gerretsen, Jelle, van Eijk, Lucas, Pickkers, Peter
發表在 Br J Clin Pharmacol (2019)

The Safety, Tolerability, and Effects on the Systemic Inflammatory Response and Renal Function of the Human Chorionic Gonadotropin Hormone-Derivative EA-230 Following On-Pump Cardi...

由 van Groenendael, Roger, Beunders, Remi, Hofland, Jan, Morshuis, Wim J, Kox, Matthijs, van Eijk, Lucas T, Pickkers, Peter
發表在 JMIR Res Protoc (2019)

Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia

由 Kiers, Dorien, van Eijk, Lucas T., van der Hoeven, Johannes G., Swinkels, Dorine W., Pickkers, Peter, Kox, Matthijs
發表在 Haematologica (2019)

Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study

由 van Eijk, Lucas T, Kroot, Joyce JC, Tromp, Mirjam, van der Hoeven, Johannes G, Swinkels, Dorine W, Pickkers, Peter
出版 2011

Endotoxemia-Induced Release of Pro-inflammatory Mediators Are Associated With Increased Glomerular Filtration Rate in Humans in vivo

由 Beunders, Remi, Schütz, Maren J., van Groenendael, Roger, Leijte, Guus P., Kox, Matthijs, van Eijk, Lucas T., Pickkers, Peter
發表在 Front Med (Lausanne) (2020)

Microvascular permeability during experimental human endotoxemia: an open intervention study

由 van Eijk, Lucas TGJ, Pickkers, Peter, Smits, Paul, Broek, Wim van den, Bouw, Martijn PWJM, van der Hoeven, Johannes G
出版 2005

Inflammation-associated changes in lipid composition and the organization of the erythrocyte membrane

由 Dinkla, Sip, van Eijk, Lucas T., Fuchs, Beate, Schiller, Jürgen, Joosten, Irma, Brock, Roland, Pickkers, Peter, Bosman, Giel J.C.G.M.
發表在 BBA Clin (2016)

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

由 Kox, Matthijs, van Eijk, Lucas T., Zwaag, Jelle, van den Wildenberg, Joanne, Sweep, Fred C. G. J., van der Hoeven, Johannes G., Pickkers, Peter
出版 2014

Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study

由 Kox, Matthijs, van Eijk, Lucas T., Verhaak, Tim, Frenzel, Tim, Kiers, Harmke D., Gerretsen, Jelle, van der Hoeven, Johannes G., Kornet, Lilian, Scheiner, Avram, Pickkers, Peter
發表在 Arthritis Res Ther (2015)

Systemic Inflammation Decreases Pain Threshold in Humans In Vivo

由 de Goeij, Moniek, van Eijk, Lucas T., Vanelderen, Pascal, Wilder-Smith, Oliver H., Vissers, Kris C., van der Hoeven, Johannes G., Kox, Matthijs, Scheffer, Gert Jan, Pickkers, Peter
出版 2013

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys

由 Schwoebel, Frank, van Eijk, Lucas T., Zboralski, Dirk, Sell, Simone, Buchner, Klaus, Maasch, Christian, Purschke, Werner G., Humphrey, Martin, Zöllner, Stefan, Eulberg, Dirk, Morich, Frank, Pickkers, Peter, Klussmann, Sven
出版 2013

The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial

由 van Eijk, Lucas T., Heemskerk, Suzanne, van der Pluijm, Rob W., van Wijk, Susanne M., Peters, Wilbert H.M., van der Hoeven, Johannes G., Kox, Matthijs, Swinkels, Dorine W, Pickkers, Peter
出版 2014

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans

由 van Eijk, Lucas T., John, Aaron S. E., Schwoebel, Frank, Summo, Luciana, Vauléon, Stéphanie, Zöllner, Stefan, Laarakkers, Coby M., Kox, Matthijs, van der Hoeven, Johannes G., Swinkels, Dorine W., Riecke, Kai, Pickkers, Peter
出版 2014

Safety and Efficacy of Human Chorionic Gonadotropin Hormone-Derivative EA-230 in Cardiac Surgery Patients: A Randomized Double-Blind Placebo-Controlled Study

由 van Groenendael, Roger, Beunders, Remi, Hemelaar, Pleun, Hofland, Jan, Morshuis, Wim J., van der Hoeven, Johannes G., Gerretsen, Jelle, Wensvoort, Gert, Kooistra, Emma J., Claassen, Wout J., Waanders, Denise, Lamberts, Maud G. A., Buijsse, Leonie S. E., Kox, Matthijs, van Eijk, Lucas T., Pickkers, Peter
發表在 Crit Care Med (2021)

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation

由 Kiers, Dorien, Wielockx, Ben, Peters, Esther, van Eijk, Lucas T., Gerretsen, Jelle, John, Aaron, Janssen, Emmy, Groeneveld, Rianne, Peters, Mara, Damen, Lars, Meneses, Ana M., Krüger, Anja, Langereis, Jeroen D., Zomer, Aldert L., Blackburn, Michael R., Joosten, Leo A., Netea, Mihai G., Riksen, Niels P., van der Hoeven, Johannes G., Scheffer, Gert-Jan, Eltzschig, Holger K., Pickkers, Peter, Kox, Matthijs
發表在 EBioMedicine (2018)