Moving molecular targeted drug therapy towards personalized medicine: Issues related to clinical trial design

di Verweij, Jaap, de Jonge, Maja, Eskens, Ferry, Sleijfer, Stefan
Pubblicato in Mol Oncol (2012)

Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor

di Hamberg, Paul, Woo, Margaret M., Chen, Lin-Chi, Verweij, Jaap, Porro, Maria Grazia, Zhao, Lily, Li, Wenkui, van der Biessen, Diane, Sharma, Sunil, Hengelage, Thomas, de Jonge, Maja
Pubblicazione 2011

The c-Met tyrosine kinase inhibitor JNJ-38877605 causes renal toxicity through species specific insoluble metabolite formation

di Lolkema, Martijn P., Bohets, Hilde H., Arkenau, Hendrik-Tobias, Lampo, Ann, Barale, Erio, de Jonge, Maja J.A., van Doorn, Leni, Hellemans, Peter, de Bono, Johann S., Eskens, Ferry A.L.M.
Pubblicato in Clin Cancer Res (2015)

A phase I pharmacokinetic and safety study of cabazitaxel in adult cancer patients with normal and impaired renal function

di Azaro, Analía, Rodón, Jordi, Machiels, Jean-Pascal, Rottey, Sylvie, Damian, Silvia, Baird, Richard, Garcia-Corbacho, Javier, Mathijssen, Ron H. J., Clot, Pierre-François, Wack, Claudine, Shen, Liji, de Jonge, Maja J. A.
Pubblicato in Cancer Chemother Pharmacol (2016)

A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours

di de Weger, Vincent A., de Jonge, Maja, Langenberg, Marlies H. G., Schellens, Jan H. M., Lolkema, Martijn, Varga, Andrea, Demers, Brigitte, Thomas, Koruth, Hsu, Karl, Tuffal, Gilles, Goodstal, Samantha, Macé, Sandrine, Deutsch, Eric
Pubblicato in Br J Cancer (2018)

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

di Steeghs, Neeltje, Mathijssen, Ron H. J., Wessels, Judith A. M., de Graan, Anne-Joy, van der Straaten, Tahar, Mariani, Mariangela, Laffranchi, Bernard, Comis, Silvia, de Jonge, Maja J. A., Gelderblom, Hans, Guchelaar, Henk-Jan
Pubblicazione 2010

Evaluation of Patient Enrollment in Oncology Phase I Clinical Trials

di van der Biessen, Diane A.J., Cranendonk, Merlijn A., Schiavon, Gaia, van der Holt, Bronno, Wiemer, Erik A.C., Eskens, Ferry A.L.M., Verweij, Jaap, de Jonge, Maja J.A., Mathijssen, Ron H.J.
Pubblicazione 2013

TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma

di Jung, Joonil, Lee, Joon Sang, Dickson, Mark A., Schwartz, Gary K., Le Cesne, Axel, Varga, Andrea, Bahleda, Rastilav, Wagner, Andrew J., Choy, Edwin, de Jonge, Maja J., Light, Madelyn, Rowley, Steve, Macé, Sandrine, Watters, James
Pubblicato in Nat Commun (2016)

Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours

di Rodon, Jordi, Argilés, Guillem, Connolly, Roisin M., Vaishampayan, Ulka, de Jonge, Maja, Garralda, Elena, Giannakis, Marios, Smith, David C., Dobson, Jason R., McLaughlin, Margaret E., Seroutou, Abdelkader, Ji, Yan, Morawiak, Jennifer, Moody, Susan E., Janku, Filip
Pubblicato in Br J Cancer (2021)

Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520

di Verheijen, Remy B., van der Biessen, Diane A. J., Hotte, Sebastien J., Siu, Lillian L., Spreafico, Anna, de Jonge, Maja J. A., Pronk, Linda C., De Vos, Filip Y. F. L., Schnell, David, Hirte, Hal W., Steeghs, Neeltje, Lolkema, Martijn P.
Pubblicato in Target Oncol (2019)

A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours

di van Bussel, Mark T. J., Awada, Ahmad, de Jonge, Maja J. A., Mau-Sørensen, Morten, Nielsen, Dorte, Schöffski, Patrick, Verheul, Henk M. W., Sarholz, Barbara, Berghoff, Karin, El Bawab, Samer, Kuipers, Mirjam, Damstrup, Lars, Diaz-Padilla, Ivan, Schellens, Jan H. M.
Pubblicato in Br J Cancer (2020)

Realizing better doctor-patient dialogue about choices in palliative care and early phase clinical trial participation: towards an online value clarification tool (OnVaCT)

di van Lent, Liza G. G., Stoel, Nicole K., van Weert, Julia C. M., van Gurp, Jelle, de Jonge, Maja J. A., Lolkema, Martijn P., Gort, Eelke H., Pulleman, Saskia M., Oomen-de Hoop, Esther, Hasselaar, Jeroen, van der Rijt, Carin C. D.
Pubblicato in BMC Palliat Care (2019)

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies

di de Jonge, Maja J. A., Steeghs, Neeltje, Lolkema, Martijn P., Hotte, Sebastien J., Hirte, Hal W., van der Biessen, Diane A. J., Abdul Razak, Albiruni R., De Vos, Filip Y. F. L., Verheijen, Remy B., Schnell, David, Pronk, Linda C., Jansen, Monique, Siu, Lillian L.
Pubblicato in Target Oncol (2019)

CMET-22. CAPMATINIB (INC280) IN METΔEX14-MUTATED ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC): EFFICACY DATA FROM THE PHASE 2 GEOMETRY MONO-1 STUDY

di Heist, Rebecca S, Seto, Takashi, Han, Ji-Youn, Reguart, Noemi, Garon, Edward B, Groen, Harry J M, Tan, Daniel S W, Hida, Toyoaki, de Jonge, Maja, V Orlov, Sergey, Smit, Egbert F, Souquet, Pierre-Jean, Vansteenkiste, Johan, Le Mouhaer, Sylvie, Robeva, Anna, Waldron-Lynch, Maeve, Giovannini, Monica, Wolf, Juergen
Pubblicato in Neuro Oncol (2019)

A phase 1 study of PARP-inhibitor ABT-767 in advanced solid tumors with BRCA1/2 mutations and high-grade serous ovarian, fallopian tube, or primary peritoneal cancer

di van der Biessen, Diane A. J., Gietema, Jourik A., de Jonge, Maja J. A., Desar, Ingrid M. E., den Hollander, Martha W., Dudley, Matthew, Dunbar, Martin, Hetman, Robert, Serpenti, Camille, Xiong, Hao, Mittapalli, Rajendar K., Timms, Kirsten M., Ansell, Peter, Ratajczak, Christine K., Shepherd, Stacie Peacock, van Herpen, Carla M. L.
Pubblicato in Invest New Drugs (2018)

Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded...

di de Leng, Wendy W. J., Gadellaa-van Hooijdonk, Christa G., Barendregt-Smouter, Françoise A. S., Koudijs, Marco J., Nijman, Ies, Hinrichs, John W. J., Cuppen, Edwin, van Lieshout, Stef, Loberg, Robert D., de Jonge, Maja, Voest, Emile E., de Weger, Roel A., Steeghs, Neeltje, Langenberg, Marlies H. G., Sleijfer, Stefan, Willems, Stefan M., Lolkema, Martijn P.
Pubblicato in PLoS One (2016)

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study

di Weeber, Fleur, Cirkel, Geert A., Hoogstraat, Marlous, Bins, Sander, Gadellaa-van Hooijdonk, Christa G.M., Ooft, Salo, van Werkhoven, Erik, Willems, Stefan M., van Stralen, Marijn, Veldhuis, Wouter B., Besselink, Nicolle J.M., Horlings, Hugo M., Steeghs, Neeltje, de Jonge, Maja J., Langenberg, Marlies H.G., Wessels, Lodewyk F.A., Cuppen, Edwin P.J.G., Schellens, J.H., Sleijfer, Stefan, Lolkema, Martijn P., Voest, Emile E.
Pubblicato in Oncotarget (2017)

53BP1 as a Potential Predictor of Response in PARP Inhibitor-Treated Homologous Recombination-Deficient Ovarian Cancer

di Hurley, Rachel M., Hendrickson, Andrea E. Wahner, Visscher, Daniel W., Ansell, Peter, Harrell, Maria I., Wagner, Jill M., Negron, Vivian, Goergen, Krista M., Maurer, Matthew J., Oberg, Ann L., Meng, X. Wei, Flatten, Karen S., De Jonge, Maja J. A., Van Herpen, Carla D., Gietema, Jourik A., Koornstra, Rutger H.T., Jager, Agnes, den Hollander, Martha W., Dudley, Matthew, Shepherd, Stacie P., Swisher, Elizabeth M., Kaufmann, Scott H.
Pubblicato in Gynecol Oncol (2019)

Implementation of a Multicenter Biobanking Collaboration for Next‐Generation Sequencing‐Based Biomarker Discovery Based on Fresh Frozen Pretreatment Tumor Tissue Biopsies

di Bins, Sander, Cirkel, Geert A., Gadellaa‐Van Hooijdonk, Christa G., Weeber, Fleur, Numan, Isaac J., Bruggink, Annette H., van Diest, Paul J., Willems, Stefan M., Veldhuis, Wouter B., van den Heuvel, Michel M., de Knegt, Rob J., Koudijs, Marco J., van Werkhoven, Erik, Mathijssen, Ron H.J., Cuppen, Edwin, Sleijfer, Stefan, Schellens, Jan H.M., Voest, Emile E., Langenberg, Marlies H.G., de Jonge, Maja J.A., Steeghs, Neeltje, Lolkema, Martijn P.
Pubblicato in Oncologist (2016)