The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

di Huang, Xianhai, Aslanian, Robert, Zhou, Wei, Zhu, Xiaohong, Qin, Jun, Greenlee, William, Zhu, Zhaoning, Zhang, Lili, Hyde, Lynn, Chu, Inhou, Cohen-Williams, Mary, Palani, Anandan
Pubblicazione 2010

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

di Qin, Jun, Zhou, Wei, Huang, Xianhai, Dhondi, Pawan, Palani, Anandan, Aslanian, Robert, Zhu, Zhaoning, Greenlee, William, Cohen-Williams, Mary, Jones, Nicholas, Hyde, Lynn, Zhang, Lili
Pubblicazione 2011

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

di Zhao, Zhiqiang, Pissarnitski, Dmitri A., Huang, Xianhai, Palani, Anandan, Zhu, Zhaoning, Greenlee, William J., Hyde, Lynn A., Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Parker, Eric M.
Pubblicato in ACS Med Chem Lett (2017)

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

di Huang, Xianhai, Zhou, Wei, Liu, Xiaoxiang, Li, Hongmei, Sun, George, Mandal, Mihirbaran, Vicarel, Monica, Zhu, Xiaohong, Bennett, Chad, McCraken, Troy, Pissarnitski, Dmitri, Zhao, Zhiqiang, Cole, David, Gallo, Gioconda, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarniecki, Michael, Greenlee, William, Burnett, Duane, Cohen-Williams, Mary, Hyde, Lynn, Song, Lixin, Zhang, Lili, Chu, Inhou, Buevich, Alexei
Pubblicazione 2012

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

di Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian A., Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H., Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Parker, Eric M., Greenlee, William J.
Pubblicazione 2012