The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

Tekijä Huang, Xianhai, Aslanian, Robert, Zhou, Wei, Zhu, Xiaohong, Qin, Jun, Greenlee, William, Zhu, Zhaoning, Zhang, Lili, Hyde, Lynn, Chu, Inhou, Cohen-Williams, Mary, Palani, Anandan
Julkaistu 2010

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

Tekijä Qin, Jun, Zhou, Wei, Huang, Xianhai, Dhondi, Pawan, Palani, Anandan, Aslanian, Robert, Zhu, Zhaoning, Greenlee, William, Cohen-Williams, Mary, Jones, Nicholas, Hyde, Lynn, Zhang, Lili
Julkaistu 2011

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

Tekijä Zhao, Zhiqiang, Pissarnitski, Dmitri A., Huang, Xianhai, Palani, Anandan, Zhu, Zhaoning, Greenlee, William J., Hyde, Lynn A., Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Parker, Eric M.
Julkaisussa ACS Med Chem Lett (2017)

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

Tekijä Huang, Xianhai, Zhou, Wei, Liu, Xiaoxiang, Li, Hongmei, Sun, George, Mandal, Mihirbaran, Vicarel, Monica, Zhu, Xiaohong, Bennett, Chad, McCraken, Troy, Pissarnitski, Dmitri, Zhao, Zhiqiang, Cole, David, Gallo, Gioconda, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarniecki, Michael, Greenlee, William, Burnett, Duane, Cohen-Williams, Mary, Hyde, Lynn, Song, Lixin, Zhang, Lili, Chu, Inhou, Buevich, Alexei
Julkaistu 2012

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

Tekijä Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian A., Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H., Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Parker, Eric M., Greenlee, William J.
Julkaistu 2012