The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators

por Huang, Xianhai, Aslanian, Robert, Zhou, Wei, Zhu, Xiaohong, Qin, Jun, Greenlee, William, Zhu, Zhaoning, Zhang, Lili, Hyde, Lynn, Chu, Inhou, Cohen-Williams, Mary, Palani, Anandan
Publicado 2010

Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators

por Qin, Jun, Zhou, Wei, Huang, Xianhai, Dhondi, Pawan, Palani, Anandan, Aslanian, Robert, Zhu, Zhaoning, Greenlee, William, Cohen-Williams, Mary, Jones, Nicholas, Hyde, Lynn, Zhang, Lili
Publicado 2011

Discovery of a Tetrahydrobenzisoxazole Series of γ-Secretase Modulators

por Zhao, Zhiqiang, Pissarnitski, Dmitri A., Huang, Xianhai, Palani, Anandan, Zhu, Zhaoning, Greenlee, William J., Hyde, Lynn A., Song, Lixin, Terracina, Giuseppe, Zhang, Lili, Parker, Eric M.
Publicado en ACS Med Chem Lett (2017)

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

por Huang, Xianhai, Zhou, Wei, Liu, Xiaoxiang, Li, Hongmei, Sun, George, Mandal, Mihirbaran, Vicarel, Monica, Zhu, Xiaohong, Bennett, Chad, McCraken, Troy, Pissarnitski, Dmitri, Zhao, Zhiqiang, Cole, David, Gallo, Gioconda, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarniecki, Michael, Greenlee, William, Burnett, Duane, Cohen-Williams, Mary, Hyde, Lynn, Song, Lixin, Zhang, Lili, Chu, Inhou, Buevich, Alexei
Publicado 2012

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

por Stamford, Andrew W., Scott, Jack D., Li, Sarah W., Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N., Gilbert, Eric J., Huang, Chunli, McKittrick, Brian A., Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H., Kennedy, Matthew E., Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A., Cox, Kathleen, Favreau, Leonard, Parker, Eric M., Greenlee, William J.
Publicado 2012