JAK2(V617F)/TET2 mutations: does the order matter?

Por Pronier, Elodie, Quivoron, Cyril, Bernard, Olivier A., Villeval, Jean-Luc
Publicado em 2011

Ligand-independent Thrombopoietin Mutant Receptor Requires Cell Surface Localization for Endogenous Activity

Por Marty, Caroline, Chaligné, Ronan, Lacout, Catherine, Constantinescu, Stefan N., Vainchenker, William, Villeval, Jean-Luc
Publicado em 2009

Co-targeting the PI3K/mTOR and JAK2 signalling pathways produces synergistic activity against myeloproliferative neoplasms

Por Bartalucci, Niccolò, Tozzi, Lorenzo, Bogani, Costanza, Martinelli, Serena, Rotunno, Giada, Villeval, Jean-Luc, Vannucchi, Alessandro M
Publicado em 2013

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice

Por Debeurme, Franck, Lacout, Catherine, Moratal, Claudine, Bagley, Rebecca G, Vainchenker, William, Adrian, Francisco, Villeval, Jean-Luc
Publicado no J Cell Mol Med (2015)

Aegyptin, a Novel Mosquito Salivary Gland Protein Specifically Binds to Collagen and Prevents its Interaction with Glycoprotein VI, Integrin α2β1 and von Willebrand Factor

Por Calvo, Eric, Tokumasu, Fuyuki, Marinotti, Osvaldo, Villeval, Jean-Luc, Ribeiro, José M. C., Francischetti, Ivo M. B.
Publicado em 2007

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis

Por Bartalucci, Niccolò, Calabresi, Laura, Balliu, Manjola, Martinelli, Serena, Rossi, Maria Caterina, Villeval, Jean Luc, Annunziato, Francesco, Guglielmelli, Paola, Vannucchi, Alessandro M.
Publicado no Oncotarget (2017)

Hemostatic disorders in a JAK2(V617F)-driven mouse model of myeloproliferative neoplasm

Por Lamrani, Lamia, Lacout, Catherine, Ollivier, Véronique, Denis, Cécile V., Gardiner, Elizabeth, Ho Tin Noe, Benoit, Vainchenker, William, Villeval, Jean-Luc, Jandrot-Perrus, Martine
Publicado em 2014

p19(INK4d) Controls Hematopoietic Stem Cells in a Cell-Autonomous Manner during Genotoxic Stress and through the Microenvironment during Aging

Por Hilpert, Morgane, Legrand, Céline, Bluteau, Dominique, Balayn, Natalie, Betems, Aline, Bluteau, Olivier, Villeval, Jean-Luc, Louache, Fawzia, Gonin, Patrick, Debili, Najet, Plo, Isabelle, Vainchenker, William, Gilles, Laure, Raslova, Hana
Publicado no Stem Cell Reports (2014)

Vascular endothelial cell expression of JAK2(V617F) is sufficient to promote a pro-thrombotic state due to increased P-selectin expression

Por Guy, Alexandre, Gourdou-Latyszenok, Virginie, Le Lay, Nicolas, Peghaire, Claire, Kilani, Badr, Dias, Juliana Vieira, Duplaa, Cécile, Renault, Marie-Ange, Denis, Cécile, Villeval, Jean Luc, Boulaftali, Yacine, Jandrot-Perrus, Martine, Couffinhal, Thierry, James, Chloe
Publicado no Haematologica (2019)

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors

Por Choong, Meng Ling, Pecquet, Christian, Pendharkar, Vishal, Diaconu, Carmen C, Yong, Jacklyn Wei Yan, Tai, Shi Jing, Wang, Si Fang, Defour, Jean-Philippe, Sangthongpitag, Kanda, Villeval, Jean-Luc, Vainchenker, William, Constantinescu, Stefan N, Lee, May Ann
Publicado em 2013

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

Por Sevin, Margaux, Kubovcakova, Lucia, Pernet, Nicolas, Causse, Sébastien, Vitte, Franck, Villeval, Jean Luc, Lacout, Catherine, Cordonnier, Marine, Rodrigues-Lima, Fernando, Chanteloup, Gaétan, Mosca, Matthieu, Chrétien, Marie-Lorraine, Bastie, Jean Noël, Audia, Sylvain, Sagot, Paul, Ramla, Selim, Martin, Laurent, Gleave, Martin, Mezger, Valérie, Skoda, Radek, Plo, Isabelle, Garrido, Carmen, Girodon, François, de Thonel, Aurélie
Publicado no Nat Commun (2018)

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Por Deichmann, Annette, Hacein-Bey-Abina, Salima, Schmidt, Manfred, Garrigue, Alexandrine, Brugman, Martijn H., Hu, Jingqiong, Glimm, Hanno, Gyapay, Gabor, Prum, Bernard, Fraser, Christopher C., Fischer, Nicolas, Schwarzwaelder, Kerstin, Siegler, Maria-Luise, de Ridder, Dick, Pike-Overzet, Karin, Howe, Steven J., Thrasher, Adrian J., Wagemaker, Gerard, Abel, Ulrich, Staal, Frank J.T., Delabesse, Eric, Villeval, Jean-Luc, Aronow, Bruce, Hue, Christophe, Prinz, Claudia, Wissler, Manuela, Klanke, Chuck, Weissenbach, Jean, Alexander, Ian, Fischer, Alain, von Kalle, Christof, Cavazzana-Calvo, Marina
Publicado em 2007