The Combination of Sulfamethoxazole, Trimethoprim, and Isoniazid or Rifampin Is Bactericidal and Prevents the Emergence of Drug Resistance in Mycobacterium tuberculosis

Por Vilchèze, Catherine, Jacobs, William R.
Publicado em 2012

Characterization of Mycobacterium smegmatis Expressing the Mycobacterium tuberculosis Fatty Acid Synthase I (fas1) Gene

Por Zimhony, Oren, Vilchèze, Catherine, Jacobs, William R.
Publicado em 2004

Vitamin C Potentiates the Killing of Mycobacterium tuberculosis by the First-Line Tuberculosis Drugs Isoniazid and Rifampin in Mice

Por Vilchèze, Catherine, Kim, John, Jacobs, William R.
Publicado no Antimicrob Agents Chemother (2018)

Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction

Por Vilchèze, Catherine, Hartman, Travis, Weinrick, Brian, Jacobs, William R.
Publicado em 2013

Synthesis and biological activity of alkynoic acids derivatives against mycobacteria

Por Vilchèze, Catherine, Leung, Lawrence W., Bittman, Robert, Jacobs, William R.
Publicado no Chem Phys Lipids (2015)

Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence

Por Vilchèze, Catherine, Weinrick, Brian, Leung, Lawrence W., Jacobs, William R.
Publicado no Proc Natl Acad Sci U S A (2018)

Pyrazinoic Acid and Its n-Propyl Ester Inhibit Fatty Acid Synthase Type I in Replicating Tubercle Bacilli

Por Zimhony, Oren, Vilchèze, Catherine, Arai, Masayoshi, Welch, John T., Jacobs, William R.
Publicado em 2007

An Anaerobic-Type α-Ketoglutarate Ferredoxin Oxidoreductase Completes the Oxidative Tricarboxylic Acid Cycle of Mycobacterium tuberculosis

Por Baughn, Anthony D., Garforth, Scott J., Vilchèze, Catherine, Jacobs, William R.
Publicado em 2009

Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria

Por Cook, Gregory M., Hards, Kiel, Vilchèze, Catherine, Hartman, Travis, Berney, Michael
Publicado em 2014

NAD(+) Auxotrophy is Bacteriocidal for the Tubercle Bacilli

Por Vilchèze, Catherine, Weinrick, Brian, Wong, Ka-Wing, Chen, Bing, Jacobs, William R.
Publicado em 2010

Precise Null Deletion Mutations of the Mycothiol Synthesis Genes Reveal Their Role in Isoniazid and Ethionamide Resistance in Mycobacterium smegmatis

Por Xu, Xia, Vilchèze, Catherine, Av-Gay, Yossef, Gómez-Velasco, Anaximandro, Jacobs, William R.
Publicado em 2011

Mutually Exclusive Genotypes for Pyrazinamide and 5-Chloropyrazinamide Resistance Reveal a Potential Resistance-Proofing Strategy

Por Baughn, Anthony D., Deng, Jiaoyu, Vilchèze, Catherine, Riestra, Angelica, Welch, John T., Jacobs, William R., Zimhony, Oren
Publicado em 2010

Mutually Exclusive Genotypes for Pyrazinamide and 5-Chloropyrazinamide Resistance Reveal a Potential Resistance-Proofing Strategy

Por Baughn, Anthony D., Deng, Jiaoyu, Vilchèze, Catherine, Riestra, Angelica, Welch, John T., Jacobs, William R., Zimhony, Oren
Publicado em 2011

Anthelmintic Avermectins Kill Mycobacterium tuberculosis, Including Multidrug-Resistant Clinical Strains

Por Lim, Leah E., Vilchèze, Catherine, Ng, Carol, Jacobs, William R., Ramón-García, Santiago, Thompson, Charles J.
Publicado em 2013

Succinate Dehydrogenase is the Regulator of Respiration in Mycobacterium tuberculosis

Por Hartman, Travis, Weinrick, Brian, Vilchèze, Catherine, Berney, Michael, Tufariello, Joanne, Cook, Gregory M., Jacobs, William R.
Publicado no PLoS Pathog (2014)

Defining a temporal order of genetic requirements for development of mycobacterial biofilms

Por Yang, Yong, Thomas, Joseph, Li, Yunlong, Vilchèze, Catherine, Derbyshire, Keith M., Jacobs, William R., Ojha, Anil K.
Publicado no Mol Microbiol (2017)

Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium...

Por Vilchèze, Catherine, Morbidoni, Hector R., Weisbrod, Torin R., Iwamoto, Hiroyuki, Kuo, Mack, Sacchettini, James C., Jacobs, William R.
Publicado em 2000

Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis

Por Vilchèze, Catherine, Av-Gay, Yossef, Barnes, S. Whitney, Larsen, Michelle H., Walker, John R., Glynne, Richard J., Jacobs, William R.
Publicado em 2011

Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis

Por Vilchèze, Catherine, Hartman, Travis, Weinrick, Brian, Jain, Paras, Weisbrod, Torin R., Leung, Lawrence W., Freundlich, Joel S., Jacobs, William R.
Publicado no Proc Natl Acad Sci U S A (2017)

Acetic Acid, the Active Component of Vinegar, Is an Effective Tuberculocidal Disinfectant

Por Cortesia, Claudia, Vilchèze, Catherine, Bernut, Audrey, Contreras, Whendy, Gómez, Keyla, de Waard, Jacobus, Jacobs, William R., Kremer, Laurent, Takiff, Howard
Publicado em 2014