Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis

Persistence, manifested as drug tolerance, represents a significant obstacle to global tuberculosis control. The bactericidal drugs isoniazid and rifampicin kill greater than 99% of exponentially growing Mycobacterium tuberculosis (Mtb) cells, but the remaining cells are persisters, cells with decre...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Vilchèze, Catherine, Hartman, Travis, Weinrick, Brian, Jain, Paras, Weisbrod, Torin R., Leung, Lawrence W., Freundlich, Joel S., Jacobs, William R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410800/
https://ncbi.nlm.nih.gov/pubmed/28396391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704376114
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