Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis

Persistence, manifested as drug tolerance, represents a significant obstacle to global tuberculosis control. The bactericidal drugs isoniazid and rifampicin kill greater than 99% of exponentially growing Mycobacterium tuberculosis (Mtb) cells, but the remaining cells are persisters, cells with decre...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Vilchèze, Catherine, Hartman, Travis, Weinrick, Brian, Jain, Paras, Weisbrod, Torin R., Leung, Lawrence W., Freundlich, Joel S., Jacobs, William R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410800/
https://ncbi.nlm.nih.gov/pubmed/28396391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704376114
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