The MCL-1 BH3 Helix is an Exclusive MCL-1 inhibitor and Apoptosis Sensitizer

Por Stewart, Michelle L., Fire, Emiko, Keating, Amy E., Walensky, Loren D.
Publicado em 2010

A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-dependent Leukemia Cell Survival

Por Cohen, Nicole A., Stewart, Michelle L., Gavathiotis, Evripidis, Tepper, Jared L., Bruekner, Susanne R., Koss, Brian, Opferman, Joseph T., Walensky, Loren D.
Publicado em 2012

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers

Por LaBelle, James L., Katz, Samuel G., Bird, Gregory H., Gavathiotis, Evripidis, Stewart, Michelle L., Lawrence, Chelsea, Fisher, Jill K., Godes, Marina, Pitter, Kenneth, Kung, Andrew L., Walensky, Loren D.
Publicado em 2012

Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

Por Barclay, Lauren A., Wales, Thomas E., Garner, Thomas P., Wachter, Franziska, Lee, Susan, Guerra, Rachel M., Stewart, Michelle L., Braun, Craig R., Bird, Gregory H., Gavathiotis, Evripidis, Engen, John R., Walensky, Loren D.
Publicado no Mol Cell (2015)

MB-103 DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS

Por Hanaford, Allison, Archer, Tenley, Price, Antoinette, Kahlert, Ulf, Maciaczyk, Jarek, Nikkhah, Guido, Kim, Jong Wook, Ehrenberger, Tobias, Clemons, Paul A., Dančík, Vlado, Seashore-Ludlow, Brinton, Viswanathan, Vasanthi, Stewart, Michelle L., Rees, Matthew G., Shamji, Alykhan, Schreiber, Stuart, Fraenkel, Ernest, Pomeroy, Scott L., Mesirov, Jill P., Tamayo, Pablo, Eberhart, Charles, Raabe, Eric
Publicado no Neuro Oncol (2016)

DiSCoVERing innovative therapies for rare tumors: combining genetically accurate disease models with in silico analysis to identify novel therapeutic targets

Por Hanaford, Allison, Archer, Tenley C, Price, Antoinette, Kahlert, Ulf D., Maciaczyk, Jarek, Nikkhah, Guido, Kim, Jong Wook, Ehrenberger, Tobias, Clemons, Paul A., Dančík, Vlado, Seashore-Ludlow, Brinton, Viswanathan, Vasanthi, Stewart, Michelle L, Rees, Matthew G., Shamji, Alykhan, Schreiber, Stuart, Fraenkel, Ernest, Pomeroy, Scott L, Mesirov, Jill P, Tamayo, Pablo, Eberhart, Charles, Raabe, Eric
Publicado no Clin Cancer Res (2016)

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules

Por Basu, Amrita, Bodycombe, Nicole E., Cheah, Jaime H., Price, Edmund V., Liu, Ke, Schaefer, Giannina I., Ebright, Richard Y., Stewart, Michelle L., Ito, Daisuke, Wang, Stephanie, Bracha, Abigail L., Liefeld, Ted, Wawer, Mathias, Gilbert, Joshua C., Wilson, Andrew J., Stransky, Nicolas, Kryukov, Gregory V., Dancik, Vlado, Barretina, Jordi, Garraway, Levi A., Hon, C. Suk-Yee, Munoz, Benito, Bittker, Joshua A., Stockwell, Brent R., Khabele, Dineo, Stern, Andrew M., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Publicado em 2013