The Pharmacodynamic Impact of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, on Circulating Levels of Inflammatory Biomarkers in Patients with Psoriatic Arthritis: Substudy Res...

Por Schafer, Peter H., Chen, Peng, Fang, Lorraine, Wang, Andrew, Chopra, Rajesh
Publicado no J Immunol Res (2015)

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors

Por Perez-Aso, Miguel, Montesinos, M. Carmen, Mediero, Aránzazu, Wilder, Tuere, Schafer, Peter H., Cronstein, Bruce
Publicado no Arthritis Res Ther (2015)

Immunomodulatory Effects in a Phase II Study of Lenalidomide Combined with Cetuximab in Refractory KRAS-Mutant Metastatic Colorectal Cancer Patients

Por Gandhi, Anita K., Shi, Tao, Li, Mingyu, Jungnelius, Ulf, Romano, Alfredo, Tabernero, Josep, Siena, Salvatore, Schafer, Peter H., Chopra, Rajesh
Publicado em 2013

Combination therapy targeting the tumor microenvironment is effective in a model of human ocular melanoma

Por Mangiameli, David P, Blansfield, Joseph A, Kachala, Stephan, Lorang, Dominique, Schafer, Peter H, Muller, George W, Stirling, David I, Libutti, Steven K
Publicado em 2007

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

Por Kanakaraj, Palanisamy, Schafer, Peter H., Cavender, Druie E., Wu, Ying, Ngo, Karen, Grealish, Patrick F., Wadsworth, Scott A., Peterson, Per A., Siekierka, John J., Harris, Crafford A., Fung-Leung, Wai-Ping
Publicado em 1998

Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase...

Por Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh
Publicado no Br J Haematol (2014)

Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity

Por Gandhi, Anita K, Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E, Schafer, Peter H, Daniel, Tom O, Lopez-Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh
Publicado no Br J Haematol (2014)

JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers

Por van der Velden, Jos L. J., Ye, Ying, Nolin, James D., Hoffman, Sidra M., Chapman, David G., Lahue, Karolyn G., Abdalla, Sarah, Chen, Peng, Liu, Yong, Bennett, Brydon, Khalil, Nasreen, Sutherland, Donna, Smith, William, Horan, Gerald, Assaf, Mahmoud, Horowitz, Zebulun, Chopra, Rajesh, Stevens, Randall M., Palmisano, Maria, Janssen-Heininger, Yvonne M. W., Schafer, Peter H.
Publicado no Clin Transl Med (2016)

CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL

Por Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.
Publicado no Blood (2015)