Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment

por Kieswich, Julius, Sayers, Sophie R., Silvestre, Marta F., Harwood, Steven M., Yaqoob, Muhammad M., Caton, Paul W.
Publicado en Diabetologia (2016)

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance

por Sayers, Sophie R., Reimann, Frank, Gribble, Fiona M., Parker, Helen, Zac-Varghese, Sagen, Bloom, Stephen R., Foretz, Marc, Viollet, Benoit, Rutter, Guy A.
Publicado en PLoS One (2016)

Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake

por Cripps, Michael J., Hanna, Katie, Lavilla, Charlie, Sayers, Sophie R., Caton, Paul W., Sims, Craig, De Girolamo, Luigi, Sale, Craig, Turner, Mark D.
Publicado en Sci Rep (2017)

Disallowance of Acot7 in β-cells is required for normal glucose tolerance and insulin secretion

por Martinez-Sanchez, Aida, Pullen, Timothy J., Chabosseau, Pauline, Zhang, Qifeng, Haythorne, Elizabeth, Cane, Matthew C., Nguyen-Tu, Marie-Sophie, Sayers, Sophie R., Rutter, Guy A.
Publicado en Diabetes (2016)

Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome

por Evans, Elizabeth A., Sayers, Sophie R., Kodji, Xenia, Xia, Yue, Shaikh, Mahum, Rizvi, Alizah, Frame, James, Brain, Susan D., Philpott, Michael P., Hannen, Rosalind F., Caton, Paul W.
Publicado en Mol Metab (2020)

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes

por Sayers, Sophie R., Beavil, Rebecca L., Fine, Nicholas H. F., Huang, Guo C., Choudhary, Pratik, Pacholarz, Kamila J., Barran, Perdita E., Butterworth, Sam, Mills, Charlotte E., Cruickshank, J. Kennedy, Silvestre, Marta P., Poppitt, Sally D., McGill, Anne-Thea, Lavery, Gareth G., Hodson, David J., Caton, Paul W.
Publicado en Diabetologia (2019)