Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain

par Bigalke, Janna M., Aibara, Shintaro, Roth, Robert, Dahl, Göran, Gordon, Euan, Dorbéus, Sarah, Amunts, A., Sandmark, Jenny
Publié dans Sci Adv (2019)

Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

par Belorusova, Anna Y., Evertsson, Emma, Hovdal, Daniel, Sandmark, Jenny, Bratt, Emma, Maxvall, Ingela, Schulman, Ira G., Åkerblad, Peter, Lindstedt, Eva-Lotte
Publié dans Commun Biol (2019)

Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling

par Sandmark, Jenny, Dahl, Göran, Öster, Linda, Xu, Bingze, Johansson, Patrik, Akerud, Tomas, Aagaard, Anna, Davidsson, Pia, Bigalke, Janna M., Winzell, Maria Sörhede, Rainey, G. Jonah, Roth, Robert G.
Publié dans J Biol Chem (2018)

Discovery of AZD2716: A Novel Secreted Phospholipase A(2) (sPLA(2)) Inhibitor for the Treatment of Coronary Artery Disease

par Giordanetto, Fabrizio, Pettersen, Daniel, Starke, Ingemar, Nordberg, Peter, Dahlström, Mikael, Knerr, Laurent, Selmi, Nidhal, Rosengren, Birgitta, Larsson, Lars-Olof, Sandmark, Jenny, Castaldo, Marie, Dekker, Niek, Karlsson, Ulla, Hurt-Camejo, Eva
Publié dans ACS Med Chem Lett (2016)

Creating Novel Activated Factor XI Inhibitors through Fragment Based Lead Generation and Structure Aided Drug Design

par Fjellström, Ola, Akkaya, Sibel, Beisel, Hans-Georg, Eriksson, Per-Olof, Erixon, Karl, Gustafsson, David, Jurva, Ulrik, Kang, Daiwu, Karis, David, Knecht, Wolfgang, Nerme, Viveca, Nilsson, Ingemar, Olsson, Thomas, Redzic, Alma, Roth, Robert, Sandmark, Jenny, Tigerström, Anna, Öster, Linda
Publié dans PLoS One (2015)

Design of Selective sPLA(2)-X Inhibitor (−)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid

par Giordanetto, Fabrizio, Knerr, Laurent, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Månsson, Åsa, Dahlström, Mikael, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Wikström, Johannes, Wågberg, Maria, Brengdahl, Johan, Rohman, Mattias, Sandmark, Jenny, Åkerud, Tomas, Roth, Robert G., Jansen, Frank, Ahlqvist, Marie
Publié dans ACS Med Chem Lett (2018)

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A(2) Type X (sPLA(2)-X) Inhibitors

par Knerr, Laurent, Giordanetto, Fabrizio, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Olsson, Thomas, Perkins, Tim D. J., Herslöf, Margareta, Månsson, Åsa, Dahlström, Mikael, Starke, Ingemar, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Brengdahl, Johan, Jansen, Frank, Rohman, Mattias, Sandmark, Jenny, Hallberg, Kenth, Åkerud, Tomas, Roth, Robert G., Ahlqvist, Marie
Publié dans ACS Med Chem Lett (2018)

Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

par Sandmark, Jenny, Tigerström, Anna, Akerud, Tomas, Althage, Magnus, Antonsson, Thomas, Blaho, Stefan, Bodin, Cristian, Boström, Jonas, Chen, Yantao, Dahlén, Anders, Eriksson, Per-Olof, Evertsson, Emma, Fex, Tomas, Fjellström, Ola, Gustafsson, David, Herslöf, Margareta, Hicks, Ryan, Jarkvist, Emelie, Johansson, Carina, Kalies, Inge, Karlsson Svalstedt, Birgitta, Kartberg, Fredrik, Legnehed, Anne, Martinsson, Sofia, Moberg, Andreas, Ridderström, Marianne, Rosengren, Birgitta, Sabirsh, Alan, Thelin, Anders, Vinblad, Johanna, Wellner, Annika U., Xu, Bingze, Östlund-Lindqvist, Ann-Margret, Knecht, Wolfgang
Publié dans J Biol Chem (2020)