Identification and analyses of inhibitors targeting apolipoprotein(a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function

Increased plasma concentrations of lipoprotein(a) (Lp(a)) are associated with an increased risk for cardiovascular disease. Lp(a) is composed of apolipoprotein(a) (apo(a)) covalently bound to apolipoprotein B of low-density lipoprotein (LDL). Many of apo(a)'s potential pathological properties,...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Biol Chem
मुख्य लेखकों: Sandmark, Jenny, Tigerström, Anna, Akerud, Tomas, Althage, Magnus, Antonsson, Thomas, Blaho, Stefan, Bodin, Cristian, Boström, Jonas, Chen, Yantao, Dahlén, Anders, Eriksson, Per-Olof, Evertsson, Emma, Fex, Tomas, Fjellström, Ola, Gustafsson, David, Herslöf, Margareta, Hicks, Ryan, Jarkvist, Emelie, Johansson, Carina, Kalies, Inge, Karlsson Svalstedt, Birgitta, Kartberg, Fredrik, Legnehed, Anne, Martinsson, Sofia, Moberg, Andreas, Ridderström, Marianne, Rosengren, Birgitta, Sabirsh, Alan, Thelin, Anders, Vinblad, Johanna, Wellner, Annika U., Xu, Bingze, Östlund-Lindqvist, Ann-Margret, Knecht, Wolfgang
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2020
विषय:
Molecular Bases of Disease
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7152747/
https://ncbi.nlm.nih.gov/pubmed/32132173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011251
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