Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands

Liver X receptors (LXRs) are attractive drug targets for cardiovascular disease treatment due to their role in regulating cholesterol homeostasis and immunity. The anti-atherogenic properties of LXRs have prompted development of synthetic ligands, but these cause major adverse effects—such as increa...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Commun Biol
Main Authors: Belorusova, Anna Y., Evertsson, Emma, Hovdal, Daniel, Sandmark, Jenny, Bratt, Emma, Maxvall, Ingela, Schulman, Ira G., Åkerblad, Peter, Lindstedt, Eva-Lotte
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874530/
https://ncbi.nlm.nih.gov/pubmed/31799433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0675-0
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