Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Anticancer Activities

di Roth, Howard S., Hergenrother, Paul J.
Pubblicato in Curr Med Chem (2016)

N-heterocyclic carbene-catalyzed rearrangements of vinyl sulfones()

di Atienza, Roxanne L., Roth, Howard S., Scheidt, Karl A.
Pubblicazione 2011

Synthesis of [5,6]-Bicyclic Heterocycles with a Ring-Junction Nitrogen via Rh(III)-Catalyzed C-H Functionalization of Alkenyl Azoles

di Halskov, Kim Søholm, Roth, Howard S., Ellman, Jonathan A.
Pubblicato in Angew Chem Int Ed Engl (2017)

NHC-Catalyzed Reactions of Aryloxyacetaldehydes: A Domino Elimination/Conjugate Addition/Acylation Process for the Synthesis of Substituted Coumarins

di Phillips, Eric M., Wadamoto, Manabu, Roth, Howard S., Ott, Andrew W., Scheidt, Karl A.
Pubblicazione 2009

The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

di Peh, Jessie, Fan, Timothy M., Wycislo, Kathryn L., Roth, Howard S., Hergenrother, Paul J.
Pubblicato in Mol Cancer Ther (2016)

Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics

di Roth, Howard S., Botham, Rachel C., Schmid, Steven C., Fan, Timothy M., Dirikolu, Levent, Hergenrother, Paul J.
Pubblicato in J Med Chem (2015)

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

di Botham, Rachel C., Roth, Howard S., Book, Alison P., Roady, Patrick J., Fan, Timothy M., Hergenrother, Paul J.
Pubblicato in ACS Cent Sci (2016)

Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)

di Hsu, Danny C., Roth, Howard S., West, Diana C., Botham, Rachel C., Novotny, Chris J., Schmid, Steven C., Hergenrother, Paul J.
Pubblicazione 2011

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant gliom...

di Joshi, Avadhut D., Botham, Rachel C., Schlein, Lisa J., Roth, Howard S., Mangraviti, Antonella, Borodovsky, Alexandra, Tyler, Betty, Joslyn, Steve, Looper, Jayme S., Podell, Michael, Fan, Timothy M., Hergenrother, Paul J., Riggins, Gregory J.
Pubblicato in Oncotarget (2017)