Derivatives of Procaspase-Activating Compound 1 (PAC-1) and Anticancer Activities

Por Roth, Howard S., Hergenrother, Paul J.
Publicado no Curr Med Chem (2016)

N-heterocyclic carbene-catalyzed rearrangements of vinyl sulfones()

Por Atienza, Roxanne L., Roth, Howard S., Scheidt, Karl A.
Publicado em 2011

Synthesis of [5,6]-Bicyclic Heterocycles with a Ring-Junction Nitrogen via Rh(III)-Catalyzed C-H Functionalization of Alkenyl Azoles

Por Halskov, Kim Søholm, Roth, Howard S., Ellman, Jonathan A.
Publicado no Angew Chem Int Ed Engl (2017)

NHC-Catalyzed Reactions of Aryloxyacetaldehydes: A Domino Elimination/Conjugate Addition/Acylation Process for the Synthesis of Substituted Coumarins

Por Phillips, Eric M., Wadamoto, Manabu, Roth, Howard S., Ott, Andrew W., Scheidt, Karl A.
Publicado em 2009

The combination of vemurafenib and procaspase-3 activation is synergistic in mutant BRAF melanomas

Por Peh, Jessie, Fan, Timothy M., Wycislo, Kathryn L., Roth, Howard S., Hergenrother, Paul J.
Publicado no Mol Cancer Ther (2016)

Removal of Metabolic Liabilities Enables Development of Derivatives of Procaspase-Activating Compound 1 (PAC-1) with Improved Pharmacokinetics

Por Roth, Howard S., Botham, Rachel C., Schmid, Steven C., Fan, Timothy M., Dirikolu, Levent, Hergenrother, Paul J.
Publicado no J Med Chem (2015)

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

Por Botham, Rachel C., Roth, Howard S., Book, Alison P., Roady, Patrick J., Fan, Timothy M., Hergenrother, Paul J.
Publicado no ACS Cent Sci (2016)

Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)

Por Hsu, Danny C., Roth, Howard S., West, Diana C., Botham, Rachel C., Novotny, Chris J., Schmid, Steven C., Hergenrother, Paul J.
Publicado em 2011

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant gliom...

Por Joshi, Avadhut D., Botham, Rachel C., Schlein, Lisa J., Roth, Howard S., Mangraviti, Antonella, Borodovsky, Alexandra, Tyler, Betty, Joslyn, Steve, Looper, Jayme S., Podell, Michael, Fan, Timothy M., Hergenrother, Paul J., Riggins, Gregory J.
Publicado no Oncotarget (2017)