Genetics of Atrial Fibrillation in 2020 – GWAS, genome sequencing, polygenic risk and beyond

Autor Roselli, Carolina, Rienstra, Michiel, Ellinor, Patrick T.
Vydáno v Circ Res (2020)

Genetic Link Between Arterial Stiffness and Atrial Fibrillation

Autor Zekavat, Seyedeh M., Roselli, Carolina, Hindy, George, Lubitz, Steven A., Ellinor, Patrick T., Zhao, Hongyu, Natarajan, Pradeep
Vydáno v Circ Genom Precis Med (2019)

Antisense regulation of atrial natriuretic peptide expression

Autor Celik, Selvi, Sadegh, Mardjaneh Karbalaei, Morley, Michael, Roselli, Carolina, Ellinor, Patrick T., Cappola, Thomas, Smith, J. Gustav, Gidlöf, Olof
Vydáno v JCI Insight (2019)

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Autor Khera, Amit V., Chaffin, Mark, Aragam, Krishna G., Haas, Mary E., Roselli, Carolina, Choi, Seung Hoan, Natarajan, Pradeep, Lander, Eric S., Lubitz, Steven A., Ellinor, Patrick T., Kathiresan, Sekar
Vydáno v Nat Genet (2018)

Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation

Autor Hall, Amelia Weber, Chaffin, Mark, Roselli, Carolina, Lin, Honghuang, Lubitz, Steven A., Bianchi, Valerio, Geeven, Geert, Bedi, Kenneth, Margulies, Kenneth B., de Laat, Wouter, Tucker, Nathan R., Ellinor, Patrick T.
Vydáno v Circ Genom Precis Med (2020)

Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results from a National Biobank

Autor Choi, Seung Hoan, Jurgens, Sean J., Weng, Lu-Chen, Pirruccello, James P., Roselli, Carolina, Chaffin, Mark, Lee, Christina, Hall, Amelia W., Khera, Amit V., Lunetta, Kathryn L., Lubitz, Steven A., Ellinor, Patrick T.
Vydáno v Circ Res (2019)

Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score: Results From the FOURIER Trial

Autor Marston, Nicholas A., Kamanu, Frederick K., Nordio, Francesco, Gurmu, Yared, Roselli, Carolina, Sever, Peter S., Pedersen, Terje R., Keech, Anthony C., Wang, Huei, Pineda, Armando Lira, Giugliano, Robert P., Lubitz, Steven A., Ellinor, Patrick T., Sabatine, Marc S., Ruff, Christian T.
Vydáno v Circulation (2019)

Heritability of Atrial Fibrillation

Autor Weng, Lu-Chen, Choi, Seung Hoan, Klarin, Derek, Smith, J. Gustav, Loh, Po-Ru, Chaffin, Mark, Roselli, Carolina, Hulme, Olivia L., Lunetta, Kathryn L., Dupuis, Josée, Benjamin, Emelia J., Newton-Cheh, Christopher, Kathiresan, Sekar, Ellinor, Patrick T., Lubitz, Steven A.
Vydáno v Circ Cardiovasc Genet (2017)

The Effect of PCSK9 Inhibition on the Risk of Venous Thromboembolism

Autor Marston, Nicholas A., Gurmu, Yared, Melloni, Giorgio E. M., Bonaca, Marc, Gencer, Baris, Sever, Peter S., Pedersen, Terje R., Keech, Anthony C., Roselli, Carolina, Lubitz, Steven A., Ellinor, Patrick T., O’Donoghue, Michelle L., Giugliano, Robert P., Ruff, Christian T., Sabatine, Marc S.
Vydáno v Circulation (2020)

Transcriptional and Cellular Diversity of the Human Heart

Autor Tucker, Nathan R., Chaffin, Mark, Fleming, Stephen J., Hall, Amelia W., Parsons, Victoria A., Bedi, Kenneth C., Akkad, Amer-Denis, Herndon, Caroline N., Arduini, Alessandro, Papangeli, Irinna, Roselli, Carolina, Aguet, François, Choi, Seung Hoan, Ardlie, Kristin G., Babadi, Mehrtash, Margulies, Kenneth B., Stegmann, Christian M., Ellinor, Patrick T.
Vydáno v Circulation (2020)

A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression

Autor Gupta, Rajat M., Hadaya, Joseph, Trehan, Aditi, Zekavat, Seyedeh M., Roselli, Carolina, Klarin, Derek, Emdin, Connor A., Hilvering, Catharina R.E., Bianchi, Valerio, Mueller, Christian, Khera, Amit V., Ryan, Russell J.H., Engreitz, Jesse M., Issner, Robbyn, Shoresh, Noam, Epstein, Charles B., de Laat, Wouter, Brown, Jonathan D., Schnabel, Renate B., Bernstein, Bradley E., Kathiresan, Sekar
Vydáno v Cell (2017)

Whole genome sequencing to characterize monogenic and polygenic contributions in patients hospitalized with early-onset myocardial infarction

Autor Khera, Amit V., Chaffin, Mark, Zekavat, Seyedeh Maryam, Collins, Ryan L., Roselli, Carolina, Natarajan, Pradeep, Lichtman, Judith H., D’Onofrio, Gail, Mattera, Jennifer, Dreyer, Rachel, Spertus, John A., Taylor, Kent D., Psaty, Bruce M., Rich, Stephen S., Post, Wendy, Gupta, Namrata, Gabriel, Stacey, Lander, Eric, Chen, Yii-Der Ida, Talkowski, Michael E., Rotter, Jerome I., Krumholz, Harlan M., Kathiresan, Sekar
Vydáno v Circulation (2019)

Genetic Risk Score to Identify Risk of Venous Thromboembolism in Patients with Cardiometabolic Disease

Autor Marston, Nicholas A., Melloni, Giorgio E.M., Gurmu, Yared, Bonaca, Marc P., Kamanu, Frederick K., Roselli, Carolina, Lee, Christina, Cavallari, Ilaria, Giugliano, Robert P., Scirica, Benjamin M., Bhatt, Deepak L., Steg, Philippe Gabriel., Cohen, Marc, Storey, Robert F., Keech, Anthony C., Raz, Itamar, Mosenzon, Ofri, Braunwald, Eugene, Lubitz, Steven A., Ellinor, Patrick T., Sabatine, Marc S., Ruff, Christian T.
Vydáno v Circ Genom Precis Med (2021)

Whole Exome Sequencing in Atrial Fibrillation

Autor Lubitz, Steven A., Brody, Jennifer A., Bihlmeyer, Nathan A., Roselli, Carolina, Weng, Lu-Chen, Christophersen, Ingrid E., Alonso, Alvaro, Boerwinkle, Eric, Gibbs, Richard A., Bis, Joshua C., Cupples, L. Adrienne, Mohler, Peter J., Nickerson, Deborah A., Muzny, Donna, Perez, Marco V., Psaty, Bruce M., Soliman, Elsayed Z., Sotoodehnia, Nona, Lunetta, Kathryn L., Benjamin, Emelia J., Heckbert, Susan R., Arking, Dan E., Ellinor, Patrick T., Lin, Honghuang
Vydáno v PLoS Genet (2016)

Genetic risk and atrial fibrillation in patients with heart failure

Autor Kloosterman, Mariëlle, Santema, Bernadet T., Roselli, Carolina, Nelson, Christopher P., Koekemoer, Andrea, Romaine, Simon. P.R., Van Gelder, Isabelle C., Lam, Carolyn S.P., Artola, Vicente A., Lang, Chim C., Ng, Leon L., Metra, Marco, Anker, Stefan, Filippatos, Gerasimos, Dickstein, Kenneth, Ponikowski, Piotr, van der Harst, Pim, van der Meer, Peter, van Veldhuisen, Dirk J., Benjamin, Emelia J., Voors, Adriaan A., Samani, Nilesh J., Rienstra, Michiel
Vydáno v Eur J Heart Fail (2020)

Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients with Cardiometabolic Disease

Autor Marston, Nicholas A., Patel, Parth N., Kamanu, Frederick K., Nordio, Francesco, Melloni, Giorgio M, Roselli, Carolina, Gurmu, Yared, Weng, Lu-Chen, Bonaca, Marc P., Giugliano, Robert P., Scirica, Benjamin M., O’Donoghue, Michelle L., Cannon, Christopher P., Anderson, Christopher D., Bhatt, Deepak L., Steg, Philippe Gabriel, Cohen, Marc, Storey, Robert F., Sever, Peter, Keech, Anthony C., Raz, Itamar, Mosenzon, Ofri, Antman, Elliott M., Braunwald, Eugene, Ellinor, Patrick T., Lubitz, Steven A., Sabatine, Marc S., Ruff, Christian T.
Vydáno v Circulation (2020)

Genetic Risk Prediction of Atrial Fibrillation

Autor Lubitz, Steven A., Yin, Xiaoyan, Lin, Henry J., Kolek, Matthew, Smith, J. Gustav, Trompet, Stella, Rienstra, Michiel, Rost, Natalia S., Teixeira, Pedro L., Almgren, Peter, Anderson, Christopher D., Chen, Lin Y., Engström, Gunnar, Ford, Ian, Furie, Karen L., Guo, Xiuqing, Larson, Martin G., Lunetta, Kathryn L., Macfarlane, Peter W., Psaty, Bruce M., Soliman, Elsayed Z., Sotoodehnia, Nona, Stott, David J., Taylor, Kent D., Weng, Lu-Chen, Yao, Jie, Geelhoed, Bastiaan, Verweij, Niek, Siland, Joylene E., Kathiresan, Sekar, Roselli, Carolina, Roden, Dan, van der Harst, Pim, Darbar, Dawood, Jukema, J. Wouter, Melander, Olle, Rosand, Jonathan, Rotter, Jerome I., Heckbert, Susan R., Ellinor, Patrick T., Alonso, Alvaro, Benjamin, Emelia J.
Vydáno v Circulation (2016)

Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study

Autor Ellervik, Christina, Roselli, Carolina, Christophersen, Ingrid E., Alonso, Alvaro, Pietzner, Maik, Sitlani, Collen M., Trompet, Stella, Arking, Dan E., Geelhoed, Bastiaan, Guo, Xiuqing, Kleber, Marcus E., Lin, Henry J., Lin, Honghuang, MacFarlane, Peter, Selvin, Elizabeth, Shaffer, Christian, Smith, Albert V., Verweij, Niek, Weiss, Stefan, Cappola, Anne R., Dörr, Marcus, Gudnason, Vilmundur, Heckbert, Susan, Mooijaart, Simon, März, Winfried, Psaty, Bruce M., Ridker, Paul M., Roden, Dan, Stott, David J., Völzke, Henry, Benjamin, Emelia J., Delgado, Graciela, Ellinor, Patrick, Homuth, Georg, Köttgen, Anna, Jukema, Johan W., Lubitz, Steven A., Mora, Samia, Rienstra, Michiel, Rotter, Jerome I., Shoemaker, M. Benjamin, Sotoodehnia, Nona, Taylor, Kent D., van der Harst, Pim, Albert, Christine M., Chasman, Daniel I.
Vydáno v JAMA Cardiol (2019)

Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation

Autor Shoemaker, M. Benjamin, Husser, Daniela, Roselli, Carolina, Jazairi, Meelad Al, Chrispin, Jonathan, Kühne, Michael, Neumann, Benjamin, Knight, Stacey, Sun, Han, Mohanty, Sanghamitra, Shaffer, Christian, Thériault, Sébastien, Rinke, Lauren Lee, Siland, Joylene E., Crawford, Diane M., Ueberham, Laura, Zardkoohi, Omeed, Büttner, Petra, Geelhoed, Bastiaan, Blum, Steffen, Aeschbacher, Stefanie, Smith, Jonathan D., Van Wagoner, David R., Freudling, Rebecca, Müller-Nurasyid, Martina, Montgomery, Jay, Yoneda, Zachary, Wells, Quinn, Issa, Tariq, Weeke, Peter, Jacobs, Victoria, Van Gelder, Isabelle C., Hindricks, Gerhard, Barnard, John, Calkins, Hugh, Darbar, Dawood, Michaud, Greg, Kääb, Stefan, Ellinor, Patrick, Natale, Andrea, Chung, Mina, Nazarian, Saman, Cutler, Michael J., Sinner, Moritz F., Conen, David, Rienstra, Michiel, Bollmann, Andreas, Roden, Dan M., Lubitz, Steven
Vydáno v Circ Arrhythm Electrophysiol (2020)

Association between titin loss-of-function variants and early-onset atrial fibrillation

Autor Choi, Seung Hoan, Lu-Chen, Weng, Roselli, Carolina, Lin, Honghuang, Haggerty, Christopher M., Shoemaker, M. Benjamin, Barnard, John, Arking, Dan E., Chasman, Daniel I., Albert, Christine M., Chaffin, Mark, Tucker, Nathan R., Smith, Jonathan D., Gupta, Namrata, Gabriel, Stacey, Margolin, Lauren, Shea, Marisa A., Shaffer, Christian M., Yoneda, Zachary T., Boerwinkle, Eric, Smith, Nicholas L., Silverman, Edwin K., Redline, Susan, Vasan, Ramachandran S., Burchard, Esteban G., Gogarten, Stephanie M., Laurie, Cecelia, Blackwell, Thomas W., Abecasis, Gonçalo, Carey, David J., Fornwalt, Brandon K., Smelser, Diane T., Baras, Aris, Dewey, Frederick E., Jaquish, Cashell E., Papanicolaou, George J., Sotoodehnia, Nona, Van Wagoner, David R., Psaty, Bruce M., Kathiresan, Sekar, Darbar, Dawood, Alonso, Alvaro, Heckbert, Susan R., Chung, Mina K., Roden, Dan M., Benjamin, Emelia J., Murray, Michael F., Lunetta, Kathryn L., Lubitz, Steven A., Ellinor, Patrick T.
Vydáno v JAMA (2018)