Pharmacokinetic and Pharmacodynamic Properties of Canakinumab, a Human Anti-Interleukin-1β Monoclonal Antibody

Por Chakraborty, Abhijit, Tannenbaum, Stacey, Rordorf, Christiane, Lowe, Philip J., Floch, David, Gram, Hermann, Roy, Sandip
Publicado em 2012

Canakinumab (ACZ885, a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)

Por Kuemmerle-Deschner, Jasmin B, Ramos, Eduardo, Blank, Norbert, Roesler, Joachim, Felix, Sandra D, Jung, Thomas, Stricker, Kirstin, Chakraborty, Abhijit, Tannenbaum, Stacey, Wright, Andrew M, Rordorf, Christiane
Publicado em 2011

In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

Por Lachmann, Helen J., Lowe, Philip, Felix, Sandra Daniela, Rordorf, Christiane, Leslie, Kieron, Madhoo, Sheril, Wittkowski, Helmut, Bek, Stephan, Hartmann, Nicole, Bosset, Sophie, Hawkins, Philip N., Jung, Thomas
Publicado em 2009

The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

Por Alten, Rieke, Gram, Hermann, Joosten, Leo A, Berg, Wim B van den, Sieper, Joachim, Wassenberg, Siegfrid, Burmester, Gerd, van Riel, Piet, Diaz-Lorente, Maria, Bruin, Gerardus JM, Woodworth, Thasia G, Rordorf, Christiane, Batard, Yannik, Wright, Andrew M, Jung, Thomas
Publicado em 2008

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

Por Skvara, Hans, Dawid, Markus, Kleyn, Elise, Wolff, Barbara, Meingassner, Josef G., Knight, Hilary, Dumortier, Thomas, Kopp, Tamara, Fallahi, Nasanin, Stary, Georg, Burkhart, Christoph, Grenet, Olivier, Wagner, Juergen, Hijazi, Youssef, Morris, Randall E., McGeown, Claire, Rordorf, Christiane, Griffiths, Christopher E.M., Stingl, Georg, Jung, Thomas
Publicado em 2008