The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

PKC isoforms t, α, and β play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several cytokines by activated human T cells, keratinocytes, and macrophages in vitro and inhibits an acute allerg...

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Detalhes bibliográficos
Main Authors: Skvara, Hans, Dawid, Markus, Kleyn, Elise, Wolff, Barbara, Meingassner, Josef G., Knight, Hilary, Dumortier, Thomas, Kopp, Tamara, Fallahi, Nasanin, Stary, Georg, Burkhart, Christoph, Grenet, Olivier, Wagner, Juergen, Hijazi, Youssef, Morris, Randall E., McGeown, Claire, Rordorf, Christiane, Griffiths, Christopher E.M., Stingl, Georg, Jung, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2496962/
https://ncbi.nlm.nih.gov/pubmed/18688284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35636
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