The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

PKC isoforms t, α, and β play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several cytokines by activated human T cells, keratinocytes, and macrophages in vitro and inhibits an acute allerg...

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Autors principals: Skvara, Hans, Dawid, Markus, Kleyn, Elise, Wolff, Barbara, Meingassner, Josef G., Knight, Hilary, Dumortier, Thomas, Kopp, Tamara, Fallahi, Nasanin, Stary, Georg, Burkhart, Christoph, Grenet, Olivier, Wagner, Juergen, Hijazi, Youssef, Morris, Randall E., McGeown, Claire, Rordorf, Christiane, Griffiths, Christopher E.M., Stingl, Georg, Jung, Thomas
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2496962/
https://ncbi.nlm.nih.gov/pubmed/18688284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35636
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