In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromes

The investigation of interleukin 1β (IL-1β) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human plasma. We demonstrate that by administering the anti–human IL-1β antibody canakinumab (ACZ885) to humans, the resulting formation of IL-1β–antibody complexes...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lachmann, Helen J., Lowe, Philip, Felix, Sandra Daniela, Rordorf, Christiane, Leslie, Kieron, Madhoo, Sheril, Wittkowski, Helmut, Bek, Stephan, Hartmann, Nicole, Bosset, Sophie, Hawkins, Philip N., Jung, Thomas
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2009
Sujets:
Brief Definitive Report
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715040/
https://ncbi.nlm.nih.gov/pubmed/19364880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082481
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