Assessing Bladder Cancer Risk in Type 2 Diabetes Clinical Trials: the Dapagliflozin Drug Development Program as a ‘Case Study’

par Ptaszynska, Agata, Cohen, Samuel M., Messing, Edward M., Reilly, Timothy P., Johnsson, Eva, Johnsson, Kristina
Publié dans Diabetes Ther (2015)

Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus

par Whaley, Jean M, Tirmenstein, Mark, Reilly, Timothy P, Poucher, Simon M, Saye, JoAnne, Parikh, Shamik, List, James F
Publié 2012

Mice Lacking Natural Killer T Cells Are More Susceptible to Metabolic Alterations following High Fat Diet Feeding

par Martin-Murphy, Brittany V., You, Qiang, Wang, Hong, De La Houssaye, Becky A., Reilly, Timothy P., Friedman, Jacob E., Ju, Cynthia
Publié 2014

Carcinogenicity Risk Assessment Supports the Chronic Safety of Dapagliflozin, an Inhibitor of Sodium–Glucose Co-Transporter 2, in the Treatment of Type 2 Diabetes Mellitus

par Reilly, Timothy P., Graziano, Michael J., Janovitz, Evan B., Dorr, Thomas E., Fairchild, Craig, Lee, Francis, Chen, Jian, Wong, Tai, Whaley, Jean M., Tirmenstein, Mark
Publié 2014

Drug-induced Allergic Hepatitis Developed in Mice When Myeloid-Derived Suppressor Cells Were Depleted Prior to Halothane Treatment

par Chakraborty, Mala, Fullerton, Aaron M., Semple, Kenrick, Chea, Lynette S., Proctor, William R., Bourdi, Mohammed, Kleiner, David E., Zeng, Xiangbin, Ryan, Pauline M., Dagur, Pradeep K., Berkson, Julia D., Reilly, Timothy P., Pohl, Lance R.
Publié dans Hepatology (2015)

Triple Therapy with MerTK and PD1 Inhibition plus Radiotherapy Promotes Abscopal Antitumor Immune Responses

par Caetano, Mauricio da Silva, Younes, Ahmed I., Barsoumian, Hampartsoum B., Quigley, Michael, Menon, Hari, Gao, Chan, Spires, Thomas, Reilly, Timothy P., Cadena, Alexandra P., Cushman, Taylor R., Schoenhals, Jonathan E., Li, Ailin, Nguyen, Quynh-Nhu, Cortez, Maria Angelica, Welsh, James W.
Publié dans Clin Cancer Res (2019)

Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

par Schalper, Kurt A., Carleton, Michael, Zhou, Ming, Chen, Tian, Feng, Ye, Huang, Shu-Pang, Walsh, Alice M., Baxi, Vipul, Pandya, Dimple, Baradet, Timothy, Locke, Darren, Wu, Qiuyan, Reilly, Timothy P., Phillips, Penny, Nagineni, Venkata, Gianino, Nicole, Gu, Jianlei, Zhao, Hongyu, Perez-Gracia, Jose Luis, Sanmamed, Miguel F., Melero, Ignacio
Publié dans Nat Med (2020)

Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma

par Barsoumian, Hampartsoum B, Ramapriyan, Rishab, Younes, Ahmed I, Caetano, Mauricio S, Menon, Hari, Comeaux, Nathan I, Cushman, Taylor R, Schoenhals, Jonathan E, Cadena, Alexandra P, Reilly, Timothy P, Chen, Dawei, Masrorpour, Fatemeh, Li, Ailin, Hong, David S, Diab, Adi, Nguyen, Quynh-Nhu, Glitza, Isabella, Ferrarotto, Renata, Chun, Stephen G, Cortez, Maria Angelica, Welsh, James
Publié dans J Immunother Cancer (2020)