Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus

Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of glucuretic, antihyperglycemic drugs that target the process of renal glucose reabsorption and induce glucuresis independently of insulin secretion or action. In patients with type 2 diabetes mellitus, SGLT2 inhibitors have been f...

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Bibliographic Details
Main Authors: Whaley, Jean M, Tirmenstein, Mark, Reilly, Timothy P, Poucher, Simon M, Saye, JoAnne, Parikh, Shamik, List, James F
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2012
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422910/
https://ncbi.nlm.nih.gov/pubmed/22923998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S22503
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