Integrated Pharmacokinetic-Driven Approach to Screen Candidate Anticancer Drugs for Brain Tumor Chemotherapy

Por Lv, Hua, Zhang, Xiaoping, Sharma, Jyoti, Reddy, M. V. Ramana, Reddy, E. Premkumar, Gallo, James M.
Publicado em 2012

ON01210.Na (Ex-RAD(®)) Mitigates Radiation Damage through Activation of the AKT Pathway

Por Kang, Anthony D., Cosenza, Stephen C., Bonagura, Marie, Manair, Manoj, Reddy, M. V. Ramana, Reddy, E. Premkumar
Publicado em 2013

Screening candidate anticancer drugs for brain tumor chemotherapy: Pharmacokinetic-driven approach for a series of (E)-N-(substituted aryl)-3-(substituted phenyl)propenamide analog...

Por Lv, Hua, Wang, Fan, Reddy, M.V. Ramana, Zhou, Qingyu, Zhang, Xiaoping, Reddy, E. Premkumar, Gallo, James M.
Publicado em 2012

Preclinical Pharmacological Evaluation of a Novel Multiple Kinase Inhibitor, ON123300, in Brain Tumor Models

Por Zhang, Xiaoping, Lv, Hua, Zhou, Qingyu, Elkholi, Rana, Chipuk, Jerry E., Reddy, M. V. Ramana, Reddy, E. Premkumar, Gallo, James M.
Publicado em 2014

A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance

Por Gumireddy, Kiranmai, Baker, Stacey J., Cosenza, Stephen C., John, Premila, Kang, Anthony D., Robell, Kimberly A., Reddy, M. V. Ramana, Reddy, E. Premkumar
Publicado em 2005

Discovery of a Clinical Stage Multi Kinase Inhibitor Sodium (E)-2-{2-Methoxy-5-[(2′, 4′, 6′-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): Synthesis, Structure...

Por Reddy, M.V. Ramana, Venkatapuram, Padmavathi, Mallireddigari, Muralidhar R, Pallela, Venkat R, Cosenza, Stephen C, Robell, Kimberly A, Akula, Balaiah, Hoffman, Benjamin S, Reddy, E. Premkumar
Publicado no J Med Chem (2011)

(Z)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure Activity Relationship (SAR), Tubulin Polymerization and Cell Growt...

Por Reddy, M.V. Ramana, Akula, Balaiah, Cosenza, Stephen C, Lee, Clement M, Mallireddigari, Muralidhar R, Pallela, Venkat R, Subbaiah, DRC Venkata, Udofa, Andrew, Reddy, E. Premkumar
Publicado em 2012

B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development

Por Baker, Stacey J., Ma’ayan, Avi, Lieu, Yen K., John, Premila, Reddy, M. V. Ramana, Chen, Edward Y., Duan, Qiaonan, Snoeck, Hans-Willem, Reddy, E. Premkumar
Publicado em 2014

Dual Inhibition of CDK4/Rb and PI3K/AKT/mTOR Pathways by ON123300 Induces Synthetic Lethality in Mantle Cell Lymphomas

Por Divakar, Saikrishna A., Reddy, M.V. Ramana, Cosenza, Stephen C., Baker, Stacey J., Perumal, Deepak, Antonelli, Anthony C., Brody, Joshua, Akula, Balaiah, Parekh, Samir, Reddy, E. Premkumar
Publicado no Leukemia (2015)

A Non–ATP-Competitive Dual Inhibitor of JAK2(V617F) and BCR-ABL(T315I) Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition

Por Jatiani, Shashidhar S., Cosenza, Stephen C., Reddy, M.V. Ramana, Ha, Ji Hee, Baker, Stacey J., Samanta, Ajoy K., Olnes, Matthew J., Pfannes, Loretta, Sloand, Elaine M., Arlinghaus, Ralph B., Reddy, E. Premkumar
Publicado em 2010

Discovery of 8-Cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a Potent Inhibitor of Cyclin-Dependent Kinas...

Por Reddy, M. V. Ramana, Akula, Balireddy, Cosenza, Stephen C., Athuluridivakar, Saikrishna, Mallireddigari, Muralidhar R., Pallela, Venkat R., Billa, Vinay K., Subbaiah, D. R. C. Venkata, Bharathi, E. Vijaya, Vasquez-Del Carpio, Rodrigo, Padgaonkar, Amol, Baker, Stacey J., Reddy, E. Premkumar
Publicado em 2014

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

Por Athuluri-Divakar, Sai Krishna, Carpio, Rodrigo Vasquez-Del, Dutta, Kaushik, Baker, Stacey J., Cosenza, Stephen C., Basu, Indranil, Gupta, Yogesh K., Reddy, M.V. Ramana, Ueno, Lynn, Hart, Jonathan R., Vogt, Peter K., Mulholland, David, Guha, Chandan, Aggarwal, Aneel K., Reddy, E. Premkumar
Publicado no Cell (2016)