A Non–ATP-Competitive Dual Inhibitor of JAK2(V617F) and BCR-ABL(T315I) Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition

Here we report the discovery of ON044580, an α-benzoyl styryl benzyl sulfide that possesses potent inhibitory activity against two unrelated kinases, JAK2 and BCR-ABL, and exhibits cytotoxicity to human tumor cells derived from chronic myelogenous leukemia (CML) and myelodysplasia (MDS) patients or...

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Main Authors: Jatiani, Shashidhar S., Cosenza, Stephen C., Reddy, M.V. Ramana, Ha, Ji Hee, Baker, Stacey J., Samanta, Ajoy K., Olnes, Matthew J., Pfannes, Loretta, Sloand, Elaine M., Arlinghaus, Ralph B., Reddy, E. Premkumar
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2921666/
https://ncbi.nlm.nih.gov/pubmed/20717479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910371337
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