(Z)-1-Aryl-3-arylamino-2-propen-1-ones, Highly Active Stimulators of Tubulin Polymerization: Synthesis, Structure Activity Relationship (SAR), Tubulin Polymerization and Cell Growth Inhibition Studies

Tubulin, the major structural component of microtubules, is a target for the development of anticancer agents. A series of (Z)-1-Aryl-3-arylamino-2-propen-1-one (10) were synthesized and evaluated for anti-proliferative activity in cell based assay. The most active compound (Z)-1-(2- bromo-3,4,5-tri...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Reddy, M.V. Ramana, Akula, Balaiah, Cosenza, Stephen C, Lee, Clement M, Mallireddigari, Muralidhar R, Pallela, Venkat R, Subbaiah, DRC Venkata, Udofa, Andrew, Reddy, E. Premkumar
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375384/
https://ncbi.nlm.nih.gov/pubmed/22587519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300176j
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados